Considering the new T2D agents

Contributor
He Ako Hiringa
17 August 2021
Bulletin #6

Empagliflozin or dulaglutide?

When initiating either empagliflozin or dulaglutide, the newly funded second-line type 2 diabetes agents,1 choice is based primarily on predominant comorbidities, clinical features and tolerability.

But patient preference is an additional factor, with administration route influential. Dulaglutide, a subcutaneous injection, is self-administered weekly. Empagliflozin is a daily oral tablet; combination empagliflozin/metformin is available, which may aid adherence.2

Switching from empagliflozin to dulaglutide is straightforward, but vildagliptin, if used, must be stopped.2 Remember, empagliflozin and dulaglutide can be used together, but one will need self-funding.

Read the HAH Bulletin to find out more.

aHAH! moment references

  1. Pharmac. Decision to fund two new medicines for type 2 diabetes - Amended with Q&A. Jan 2021. https://tinyurl.com/afcnmfpv
  2. New Zealand Society for the Study of Diabetes. Type 2 diabetes management guidelines: Non-insulin medications. https://tinyurl.com/4xpnedte

HAH Bulletin references

  1. Pharmac. Decision to fund two new medicines for type 2 diabetes - Amended with Q&A. Jan 2021. https://tinyurl.com/afcnmfpv
  2. He Ako Hiringa. What’s new with type 2 diabetes care in 2021? Use of SGLT2 inhibitors and GLP-1 agonists. https://tinyurl.com/8va8hr2h
  3. New Zealand Society for the Study of Diabetes. Type 2 diabetes management guidelines: Non-insulin medications. https://tinyurl.com/4xpnedte
  4. Gerstein HC, Colhoun HM, Dagenais GR. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial. Lancet 2019;394(10193)121–30.
  5. BPACnz. New diabetes medicines funded: empagliflozin and dulaglutide. June 2021. https://bpac.org.nz/2021/diabetes.aspx
  6. NPS MedicineWise. Trulicity: Dulaglutide. Jul 2020. www.nps.org.au/medicine-finder/trulicity-solution-for-injection
  7. Medsafe. Jardiance (empagliflozin) data sheet. Dec 2019. www.medsafe.govt.nz/profs/Datasheet/j/jardiancetab.pdf